Pyrrolidine → HCID 68070913, compound

HRID 1469063Notes

Reaction equation

HRID 1469063 reaction equation
[CH3:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([N:16]1[CH:20]=[C:19]([C:21]([O:23]CC)=[O:22])[CH:18]=[N:17]1)[NH:10][C:9]2=O.[NH:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH3:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([N:16]1[CH:20]=[C:19]([C:21]([OH:23])=[O:22])[CH:18]=[N:17]1)[N:10]=[C:9]2[N:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136379407HCID 136379407, compound

Product 1

HCID 68070913HCID 68070913, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-((2,6-dimethylbenzyl)amino)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI/CI): predicted mass C25H26N6O2, 442.2.

Sources & evidence

ORD record
ord-ee43f4ad61ba4570a2494b6c77e0a6b5
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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