Pyrrolidine → HCID 66747419, compound

HRID 1469075Notes

Reaction equation

HRID 1469075 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([N:17]2[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]2)[NH:11][C:10]3=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([N:17]2[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]2)[N:11]=[C:10]3[N:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136379412HCID 136379412, compound

Product 1

HCID 66747419HCID 66747419, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(piperidin-1-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI/CI): predicted mass C21H24N6O2, 392.2.

Sources & evidence

ORD record
ord-afc07634e5804f7da52ddb90b84f9235
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

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