反应详情

0.50 g of 4-chloro-6-iodoquinazoline, 0.30 g of 1,2,3,4-tetrahydroquinoline and 0.40 ml of triethylamine in 4 ml of dioxane are heated at 80° C. in a flask until the quinazoline has reacted completely (HPLC check, about 24 hours). The cooled reaction solution is evaporated to dryness in a rotary evaporator. The residue is purified by means of column chromatography (gradient heptane: EA 5-100% in 16 min.), giving 0.27 g of 4-(3,4-dihydro-2H-quinolin-1-yl)-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)quinazoline as yellow solid (yield 43%, content 96%); MS-FAB (M+H+)=387.8; Rf (polar method): 2.43 min.

1. customhas reacted completely (HPLC check, about 24 hours)
2. customThe cooled reaction solution
3. customis evaporated to dryness in a rotary evaporator
4. customThe residue is purified by means of column chromatography (gradient heptane: EA 5-100% in 16 min.)