反应详情

Next, to a solution of (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester (230 mg, 1.15 mmol) in ethanol (5 mL) is added aqueous 1M NaOH (2 mL, 2.0 mmol) and the mixture is stirred at room temperature for 18 hours. The mixture is acidified with aqueous 1M HCl and the ethanol is removed under reduced pressure. The remaining aqueous solution is lyophilized to give (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid.

1. customthe ethanol is removed under reduced pressure