Hydrochloric Acid → HCID 53904370, compound

HRID 1469646Notes

Reaction equation

HRID 1469646 reaction equation
C([O:3][C:4](=[O:13])[CH2:5][C:6]1[S:7][C:8]([CH2:11][CH3:12])=[N:9][N:10]=1)C.[OH-].[Na+].Cl>C(O)C>[CH2:11]([C:8]1[S:7][C:6]([CH2:5][C:4]([OH:13])=[O:3])=[N:10][N:9]=1)[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67505705(5-Ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester

Product 1

HCID 53904370HCID 53904370, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Next, to a solution of (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester (230 mg, 1.15 mmol) in ethanol (5 mL) is added aqueous 1M NaOH (2 mL, 2.0 mmol) and the mixture is stirred at room temperature for 18 hours. The mixture is acidified with aqueous 1M HCl and the ethanol is removed under reduced pressure. The remaining aqueous solution is lyophilized to give (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid.

Workup

  1. customthe ethanol is removed under reduced pressure

Sources & evidence

ORD record
ord-5f09b867632a489193c06797c62abc44
Source dataset
uspto-grants-2015_04
Patent number
US09006249B2

Reaction notes

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