HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Pyrimidine-2,4-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Diethyl pyrimidine-2,4-dicarboxylate | HCID 66701935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Pyrimidine-2,4-dicarboxylic acid | HCID 45117348 | — |
Reaction Steps
Next, to a stirred solution of diethyl pyrimidine-2,4-dicarboxylate (130 mg, 0.58 mmol) in MeOH (3 mL) is added 1N NaOH (2 mL) and the mixture is stirred at room temperature for 3 hours. The solution is carefully acidified with 1N HCl and the solvent is removed under reduced pressure to give pyrimidine-2,4-dicarboxylic acid. This is used as is in subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006249B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-2c586ccd6bde4ebaaf501106ecffc963 |
| Source note | uspto-grants-2015_04 |