Hydrochloric Acid → Pyrimidine-2,4-dicarboxylic acid

HRID 1469673Notes

Reaction equation

HRID 1469673 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([O:9]CC)=[O:8])=[N:3][C:2]=1[C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[N:3][C:2]=1[C:12]([OH:14])=[O:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66701935Diethyl pyrimidine-2,4-dicarboxylate

Product 1

HCID 45117348Pyrimidine-2,4-dicarboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Next, to a stirred solution of diethyl pyrimidine-2,4-dicarboxylate (130 mg, 0.58 mmol) in MeOH (3 mL) is added 1N NaOH (2 mL) and the mixture is stirred at room temperature for 3 hours. The solution is carefully acidified with 1N HCl and the solvent is removed under reduced pressure to give pyrimidine-2,4-dicarboxylic acid. This is used as is in subsequent reactions.

Workup

  1. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-2c586ccd6bde4ebaaf501106ecffc963
Source dataset
uspto-grants-2015_04
Patent number
US09006249B2

Reaction notes

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