反应详情

The title compound was prepared following the procedure described in Intermediate-11, step-4 using 4-(2-fluoro-5-(trifluoromethyl)phenoxy)-8-nitroquinoline (432 mg, 1.22 mmol), iron powder (683 mg, 12.2 mmol), and NH4Cl (517 mg, 9.76 mmol) in EtOH (5 mL) and water (2 mL) to afford 330 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 8.52 (d, J=5.1 Hz, 1H), 7.94 (d, J=6.6 Hz, 1H), 7.79-7.70 (m, 2H), 7.35 (d, J=6.0 Hz, 2H), 6.91 (d, J=3.6 Hz, 1H), 6.63 (d, J=4.2 Hz, 1H), 5.98 (br s, 2H).

1. customThe title compound was prepared