HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 71678386, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,4-Difluorocyclohexan-1-amine hydrochloride | HCID 23150669 | — |
| Reactant | HCID 86692243 | HCID 86692243 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 71678386 | HCID 71678386 | 69.3% |
Reaction Steps
The title compound was prepared following the procedure described in Intermediate-15, step-1 using 4-chloro-2-methyl-8-nitroquinazoline (Intermediate-27, step-2, 200 mg, 0.896 mmol), 4,4-difluorocyclohexanamine hydrochloride (228 mg, 1.345 mmol), and K2CO3 (370 mg, 2.68 mmol) in CH3CN (4 mL) to afford 200 mg of the title product. MS [M+H]+: 323.23.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006257B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-86c20442e5304787a7bbc5632737ac09 |
| Source note | uspto-grants-2015_04 |