Potassium Carbonate → HCID 71678386, compound

HRID 1469781Notes

Reaction equation

HRID 1469781 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:15])[N:3]=1.Cl.[F:17][C:18]1([F:25])[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]1.C([O-])([O-])=O.[K+].[K+]>CC#N>[F:17][C:18]1([F:25])[CH2:23][CH2:22][CH:21]([NH:24][C:2]2[C:11]3[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:15])[N:3]=2)[CH2:20][CH2:19]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 231506694,4-Difluorocyclohexan-1-amine hydrochlorideHCID 86692243HCID 86692243, compound

Product 1

HCID 71678386HCID 71678386, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared following the procedure described in Intermediate-15, step-1 using 4-chloro-2-methyl-8-nitroquinazoline (Intermediate-27, step-2, 200 mg, 0.896 mmol), 4,4-difluorocyclohexanamine hydrochloride (228 mg, 1.345 mmol), and K2CO3 (370 mg, 2.68 mmol) in CH3CN (4 mL) to afford 200 mg of the title product. MS [M+H]+: 323.23.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-86c20442e5304787a7bbc5632737ac09
Source dataset
uspto-grants-2015_04
Patent number
US09006257B2

Reaction notes

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