2-Amino-4,5-dimethyl-1,3-thiazole → HCID 131728627, compound

HRID 1469973Notes

Reaction equation

HRID 1469973 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][Br:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]1[N:12]=[C:13]([NH2:17])[S:14][C:15]=1[CH3:16]>>[BrH:8].[C:1]([O:5][C:6](=[O:9])[CH2:7][N:12]1[C:11]([CH3:10])=[C:15]([CH3:16])[S:14][C:13]1=[NH:17])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 79177tert-Butyl bromoacetate

Product 1

HCID 131728627HCID 131728627, compound

Procedure

Bromoacetic acid tert-butyl ester (1.4 mL, 9.4 mmol) and 4,5-dimethyl-2-aminothiazole (1.0 g, 7.8 mmol) were heated at 85° C. for 14 hours. The mixture was cooled to ambient temperature and the resulting solid was triturated with ethyl acetate to provide the title compound.

Workup

  1. customthe resulting solid was triturated with ethyl acetate

Sources & evidence

ORD record
ord-96c071917e3a465c8f8a5a08a8f6d4ce
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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