(1-Bromoethyl)benzene → HCID 178435119, compound

HRID 1469985Notes

Reaction equation

HRID 1469985 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].Br[CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:11].[C:18]12([C:28](O)=[O:29])[CH2:27][CH:22]3[CH2:23][CH:24]([CH2:26][CH:20]([CH2:21]3)[CH2:19]1)[CH2:25]2>>[CH3:1][C:2]1[N:3]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])/[C:4](=[N:8]/[C:28]([C:18]23[CH2:27][CH:22]4[CH2:23][CH:24]([CH2:26][CH:20]([CH2:21]4)[CH2:19]2)[CH2:25]3)=[O:29])/[S:5][C:6]=1[CH3:7]

Participants

4

Reactant 3

HCID 11454(1-Bromoethyl)benzeneHCID 132351-Adamantanecarboxylic acidHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Product 1

HCID 178435119HCID 178435119, compound

Procedure

4,5-dimethylthiazol-2-ylamine, (1-bromo-ethyl)benzene and 1-adamantane carboxylic acid were processed according to the method of Example 47 to afford the title compound. 1H NMR (CDCl3, 500 MHz) δ ppm 1.51-1.75 (m, 12H) 1.91 (d, J=6.86 Hz, 6H) 2.03-2.11 (m, 3H) 2.14 (s, 3H) 5.98-6.31 (m, 1H) 7.21 (d, J=8.11 Hz, 2H) 7.25 (t, J=7.33 Hz, 1H) 7.34 (t, J=7.49 Hz, 2H); MS (ESI) m/z 394 (M+H)+.

Sources & evidence

ORD record
ord-a6235507650849d2b5b79e3f8e08937f
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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