2-Bromoethyl methyl ether → 3-(2-methoxyethyl)-5-(2,2,2-trifluoroethyl)thiazol-2(3H)-imine hydrobromide

HRID 1470019Notes

Reaction equation

HRID 1470019 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][C:4]1[S:8][C:7]([NH2:9])=[N:6][CH:5]=1.[CH3:12][O:13][CH2:14][CH2:15][Br:16]>>[BrH:16].[CH3:12][O:13][CH2:14][CH2:15][N:6]1[CH:5]=[C:4]([CH2:3][C:2]([F:1])([F:10])[F:11])[S:8][C:7]1=[NH:9]

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 866190515-(2,2,2-Trifluoroethyl)thiazol-2-amine

Product 1

HCID 668593353-(2-methoxyethyl)-5-(2,2,2-trifluoroethyl)thiazol-2(3H)-imine hydrobromide

Procedure

A mixture of Example 139A and commercially available 2-bromoethyl methyl ether (Aldrich) was processed using the method described in Example 46A to afford the title compound. MS (ESI+) m/z 241 (M+H)+.

Sources & evidence

ORD record
ord-78f64af53d2d4951a102fc80c6fed69e
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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