Thiourea → 4-Cyclopropyl-1,3-thiazol-2-amine

HRID 1470030Notes

Reaction equation

Br[CH2:2][C:3]([CH:5]1[CH2:7][CH2:6]1)=O.[NH2:8][C:9]([NH2:11])=[S:10]>>[CH:5]1([C:3]2[N:8]=[C:9]([NH2:11])[S:10][CH:2]=2)[CH2:7][CH2:6]1

Participants

Reactant 2

HCID 2723790Thiourea

HCID 109208412-Bromo-1-cyclopropylethan-1-one

Product 1

HCID 6744564-Cyclopropyl-1,3-thiazol-2-amine

Procedure

A mixture of 2-bromo-1-cyclopropyl-ethanone (0.50 g, 3.0 mmol, Waterstone Technology) and thiourea (0.23 g, 3.1 mmol) were processed as in Example 71A to afford the title compound. MS (DCI/NH3) m/z 141 (M+H)+.

Sources & evidence

ORD record: ord-9323089e99744939ac669f41f9acc856
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006275B2

Reaction notes

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