HCID 178504227, compound → HCID 87181398, compound

HRID 1470041Notes

Reaction equation

HRID 1470041 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13]/[C:12](=[N:14]\[C:15]([C:17]23[CH2:26][CH:21]4[CH2:22][CH:23]([CH2:25][CH:19]([CH2:20]4)[CH2:18]2)[CH2:24]3)=[O:16])/[N:11](COCC[Si](C)(C)C)[CH:10]=1>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][C:12]([NH:14][C:15]([C:17]23[CH2:26][CH:21]4[CH2:20][CH:19]([CH2:25][CH:23]([CH2:22]4)[CH2:24]2)[CH2:18]3)=[O:16])=[N:11][CH:10]=1

Participants

3

Reactant 1

HCID 178504227HCID 178504227, compound

Product 1

HCID 87181398HCID 87181398, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Example 200B in trifluoroacetic acid was heated at 50° C. for 3 hours then concentrated. The residue was diluted with saturated aqueous NaHCO3, and extracted with ethyl acetate. The organic extract was dried (Na2SO4), filtered and concentrated to afford the title compound. MS (ESI) m/z 375 (M+H)+.

Workup

  1. concentrationthen concentrated
  2. additionThe residue was diluted with saturated aqueous NaHCO3
  3. extractionextracted with ethyl acetate
  4. extractionThe organic extract
  5. dry with materialwas dried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-ca080088b8ba4abc894af440461efc4f
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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