2-Chlorocyclopentanone → 5,6-Dihydro-4H-cyclopenta[d]thiazol-2-amine hydrochloride

HRID 1470043Notes

Reaction equation

HRID 1470043 reaction equation
[Cl:1][CH:2]1[CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:8][C:9]([NH2:11])=[S:10]>>[ClH:1].[S:10]1[C:3]2[CH2:4][CH2:5][CH2:6][C:2]=2[N:8]=[C:9]1[NH2:11]

Participants

3

Reactant 2

HCID 127512-ChlorocyclopentanoneHCID 2723790Thiourea

Product 1

HCID 162532465,6-Dihydro-4H-cyclopenta[d]thiazol-2-amine hydrochloride

Conditions

Temperature
80 °C

Procedure

A mixture of 2-chlorocyclopentanone (5.00 g, 39.5 mmol) and thiourea (3.00 g, 39.5 mmol) was heated at 80° C. for 3-4 minutes. After cooling to room temperature, the mixture was triturated with ethanol and the solid was collected by filtration to afford the title compound. MS (ESI) m/z 141 (M+H)+.

Workup

  1. temperatureAfter cooling to room temperature
  2. customthe mixture was triturated with ethanol
  3. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-dde4693a6dad4f318db8fad5048e711a
Source dataset
uspto-grants-2015_04
Patent number
US09006275B2

Reaction notes

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