Potassium Hydroxide → HCID 178426257, compound

HRID 1470224Notes

Reaction equation

HRID 1470224 reaction equation
[CH3:1][C:2]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]3[N-:14][N:15]=[N:16][N:17]=3)[C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1.[K+].[OH-].[K+]>O.Cl>[CH3:1][C:2]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]3[NH:14][N:15]=[N:16][N:17]=3)[C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 443866Pemirolast potassium

Product 1

HCID 178426257HCID 178426257, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

Pemirolast free acid was prepared by dissolving pemirolast potassium in water and acidifying to pH 1 with 6M HCl which caused the free acid to precipitate from solution. The crystals formed were filtered, washed with water and dried under vacuum. Pemirolast potassium was in turn prepared analogously to the methodology described in Example 4 (steps Ia and Ib) below, using 2M KOH instead of 2M NaOH, and recrystallising from water:isopropanol in a 1:2, instead of a 2:1, ratio.

Workup

  1. customto precipitate from solution
  2. customThe crystals formed
  3. filtrationwere filtered
  4. washwashed with water
  5. customdried under vacuum
  6. customprepared analogously to the methodology
  7. customrecrystallising from water

Sources & evidence

ORD record
ord-be2ce49101144f7ea7005d3cfff820d5
Source dataset
uspto-grants-2015_04
Patent number
US09006431B2

Reaction notes

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