反应详情

Pemirolast potassium (190 g; 0.71 mol; Chemtronica AB) was dissolved in a mixture of water (2,500 mL) and THF (1,400 mL) with stirring for 1 h at room temperature. The mixture was then clear-filtered, and acetic acid (43 g, 0.72 mol) in water (400 mL) was added in 2 portions. Firstly, approximately 50 mL of the mixture was added and the resultant slurry stirred for 30 minutes. Then, the rest of the acetic acid solution was added slowly. The resultant slurry was equilibrated over 2 hours, filtered and washed with water. The sub-title compound was air-dried overnight and then dried in a vacuum oven at 40° C. for 24 hours. The yield was 164 g (white solid, hard clumps).

1. filtrationThe mixture was then clear-filtered
2. stirringthe resultant slurry stirred for 30 minutes
3. waitThe resultant slurry was equilibrated over 2 hours
4. filtrationfiltered
5. washwashed with water
6. dry with materialThe sub-title compound was air-dried overnight
7. customdried in a vacuum oven at 40° C. for 24 hours