反应详情

Ethyl 4-(benzyloxy)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxylate, 3-b, (150 g, 0.46 mol) in THF (1.5 L) was treated with LiOH monohydrate (58 g, 1.39 mol) in water (60 ml) at room temperature for 3 hours. The mixture was concentrated under vacuum and diluted with water (200 ml) followed by extraction with ethyl acetate. The aqueous layer was acidified to pH=2 with 10% HCl and solid crushed out from the solution which was then filtered and washed with water to afford the compound, 3-c. (40 g, 29%).

1. concentrationThe mixture was concentrated under vacuum
2. additiondiluted with water (200 ml)
3. extractionfollowed by extraction with ethyl acetate
4. customcrushed out from the solution which
5. filtrationwas then filtered
6. washwashed with water