HRID1470394

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6485362

4,5,6,7-Tetrahydro-benzo[b]thiophene-2-carbonyl chloride

C9H9ClOS

反应SMILES：Cc1c(N)cccc1-c1ccnc2cc(-c3ccc(C(=O)N4CCCC4)cc3)oc12

HCID86694440

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1c(NC(=O)c2cc3c(s2)CCCC3)cccc1-c1ccnc2cc(-c3ccc(C(=O)N4CCCC4)cc3)oc12

HCID66779332

未命名化合物

PROCEDURE

实验过程

The compound was synthesized according to the procedure M using 2-methyl-3-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]furo[3,2-b]pyridin-7-yl}aniline (40.00 mg, 0.10 mmol) and 4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl chloride (22.22 mg, 0.11 mmol). The title compound was obtained as a white solid (8.00 mg, 14%). HPLC (method F): 82%, RT=4.365. MS: m/z=562 [M+H]+, RT=4.33 min.

WORKUP

后处理

customThe compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-2da24e84efa64faba7bf7d1fd6e514c3
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09006440B2
来源说明: uspto-grants-2015_04

反应SMILES

[CH3:1][C:2]1[C:8]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)=[O:25])=[CH:20][CH:19]=4)[O:17][C:10]=23)=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[S:31]1[C:35]2[CH2:36][CH2:37][CH2:38][CH2:39][C:34]=2[CH:33]=[C:32]1[C:40](Cl)=[O:41]>>[CH3:1][C:2]1[C:8]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)=[O:25])=[CH:20][CH:19]=4)[O:17][C:10]=23)=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:40]([C:32]1[S:31][C:35]2[CH2:36][CH2:37][CH2:38][CH2:39][C:34]=2[CH:33]=1)=[O:41]