4,5,6,7-Tetrahydro-benzo[b]thiophene-2-carbonyl chloride → HCID 66779332, compound

HRID 1470394Notes

Reaction equation

HRID 1470394 reaction equation
[CH3:1][C:2]1[C:8]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)=[O:25])=[CH:20][CH:19]=4)[O:17][C:10]=23)=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[S:31]1[C:35]2[CH2:36][CH2:37][CH2:38][CH2:39][C:34]=2[CH:33]=[C:32]1[C:40](Cl)=[O:41]>>[CH3:1][C:2]1[C:8]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)=[O:25])=[CH:20][CH:19]=4)[O:17][C:10]=23)=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:40]([C:32]1[S:31][C:35]2[CH2:36][CH2:37][CH2:38][CH2:39][C:34]=2[CH:33]=1)=[O:41]

Participants

3

Reactant 2

HCID 64853624,5,6,7-Tetrahydro-benzo[b]thiophene-2-carbonyl chlorideHCID 86694440HCID 86694440, compound

Product 1

HCID 66779332HCID 66779332, compound

Procedure

The compound was synthesized according to the procedure M using 2-methyl-3-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]furo[3,2-b]pyridin-7-yl}aniline (40.00 mg, 0.10 mmol) and 4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl chloride (22.22 mg, 0.11 mmol). The title compound was obtained as a white solid (8.00 mg, 14%). HPLC (method F): 82%, RT=4.365. MS: m/z=562 [M+H]+, RT=4.33 min.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-2da24e84efa64faba7bf7d1fd6e514c3
Source dataset
uspto-grants-2015_04
Patent number
US09006440B2

Reaction notes

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