反应详情

A stirred solution of 4-bromo-5-methylisoquinolin-1(2H)-one (Intermediate-4) (10 g, 42 mmol) in POCl3 (50 mL) was heated to 100° C. for 30 min. The reaction mixture was then poured into ice-water, extracted with CH2Cl2 (3×200 mL), washed with water (2×200 mL), dried over Na2SO4, filtered and concentrated to obtain desired compound (10 g, 92%).

1. extractionextracted with CH2Cl2 (3×200 mL)
2. washwashed with water (2×200 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated