反应详情

A stirred solution of 1-hydroxy-5-methylisoquinolin-4-carboxylic acid (Intermediate-9) (600 mg, 3 mmol) in POCl3 (10 mL) was heated to 100° C. for 40-50 min. The reaction mixture was poured into ice-water, extracted with CH2Cl2 (2×100 mL), washed with water (2×100 mL), dried over Na2SO4, filtered and evaporated to give the desired compound (550 mg, 86%).

1. extractionextracted with CH2Cl2 (2×100 mL)
2. washwashed with water (2×100 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated