4-Aminomethyltetrahydropyran → 1-Chloro-5-methyl-N-((tetrahydro-2H-pyran-4-yl)methyl)isoquinolin-4-carboxamide

HRID 1470462Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[O:16]1[CH2:21][CH2:20][CH:19]([CH2:22][NH2:23])[CH2:18][CH2:17]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([NH:23][CH2:22][CH:19]2[CH2:20][CH2:21][O:16][CH2:17][CH2:18]2)=[O:15])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 84687221HCID 84687221, compound

Product 1

HCID 866895781-Chloro-5-methyl-N-((tetrahydro-2H-pyran-4-yl)methyl)isoquinolin-4-carboxamide

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and (tetrahydro-2H-pyran-4-yl)methanamine by following the similar procedure as described for Intermediate-11a.

Sources & evidence

ORD record: ord-962ff391de5c4273b9195c239c92dad9
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006442B2

Reaction notes

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