Tert-Butylamine → N-(tert-Butyl)-1-chloro-5-methylisoquinolin-4-carboxamide

HRID 1470463Notes

Reaction equation

HRID 1470463 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([NH:20][C:13]([C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][C:7]=2[CH3:12])[C:2]([Cl:1])=[N:3][CH:4]=1)=[O:15])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 84687221HCID 84687221, compound

Product 1

HCID 86689579N-(tert-Butyl)-1-chloro-5-methylisoquinolin-4-carboxamide

Procedure

This compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and tert-butylamine by following the similar procedure as described for Intermediate-11a.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-90a383639ddd451ab48973b63ce757a0
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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