2-Oxa-6-azaspiro[3.3]heptane → (1-Chloro-5-methylisoquinolin-4-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone

HRID 1470466Notes

Reaction equation

HRID 1470466 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[CH2:16]1[C:19]2([CH2:22][NH:21][CH2:20]2)[CH2:18][O:17]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:21]2[CH2:22][C:19]3([CH2:16][O:17][CH2:18]3)[CH2:20]2)=[O:15])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 231118872-Oxa-6-azaspiro[3.3]heptaneHCID 84687221HCID 84687221, compound

Product 1

HCID 86689582(1-Chloro-5-methylisoquinolin-4-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 2-oxa-6-azaspiro[3.3]heptane by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record
ord-15884668a6c844f9add8879c51525165
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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