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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1470466Generated: November 2, 2026

2-Oxa-6-azaspiro[3.3]heptane → (1-Chloro-5-methylisoquinolin-4-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone

https://huagongshe.com/reaction/1470466

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Oxa-6-azaspiro[3.3]heptaneHCID 23111887—
ReactantHCID 84687221HCID 84687221—
Product(1-Chloro-5-methylisoquinolin-4-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanoneHCID 86689582—

Reaction Steps

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 2-oxa-6-azaspiro[3.3]heptane by following the similar procedure as described for intermediate-11a.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09006442B2
Source datasetuspto-grants-2015_04
ORD IDord-15884668a6c844f9add8879c51525165
Source noteuspto-grants-2015_04