Pyrrolidine → HCID 86689589, compound

HRID 1470473Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 84687221HCID 84687221, compound

Product 1

HCID 86689589HCID 86689589, compound

Procedure

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and pyrrolidine by following the similar procedure as described for intermediate-11a.

Sources & evidence

ORD record: ord-9c918aacb8334672bb29677fb7ee1be5
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006442B2

Reaction notes

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