Trifluoromethanesulfonic anhydride → HCID 88921329, compound

HRID 1470493Notes

Reaction equation

[OH:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])=[CH:4][CH:3]=1.[O:21](S(C(F)(F)F)(=O)=O)[S:22]([C:25]([F:28])([F:27])[F:26])(=O)=[O:23]>>[F:26][C:25]([F:28])([F:27])[S:22]([O:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])=[CH:4][CH:3]=1)(=[O:23])=[O:21]

Participants

Reactant 2

HCID 67749Trifluoromethanesulfonic anhydride

HCID 68281877HCID 68281877, compound

Product 1

HCID 88921329HCID 88921329, compound

Procedure

This compound was prepared by treating (4-hydroxy-8-methylnaphthalen-1-yl)(piperidin-1-yl)methanone (above step-2 intermediate) with Tf2O by following the similar procedure as described in Step-8 of Intermediate-22

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-9c8cd713e19541f98fffa9b84b0665de
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006442B2

Reaction notes

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