Trifluoromethanesulfonic anhydride → HCID 88921334, compound

HRID 1470498Notes

Reaction equation

HRID 1470498 reaction equation
[CH:1]12[CH2:6][CH:5]1[CH2:4][N:3]([C:7]([C:9]1[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[CH3:19])[C:12]([OH:20])=[CH:11][CH:10]=1)=[O:8])[CH2:2]2.[O:21](S(C(F)(F)F)(=O)=O)[S:22]([C:25]([F:28])([F:27])[F:26])(=O)=[O:23]>>[F:26][C:25]([F:28])([F:27])[S:22]([O:20][C:12]1[C:13]2[C:18](=[C:17]([CH3:19])[CH:16]=[CH:15][CH:14]=2)[C:9]([C:7]([N:3]2[CH2:2][CH:1]3[CH:5]([CH2:6]3)[CH2:4]2)=[O:8])=[CH:10][CH:11]=1)(=[O:23])=[O:21]

Participants

3

Reactant 2

HCID 67749Trifluoromethanesulfonic anhydrideHCID 68281885HCID 68281885, compound

Product 1

HCID 88921334HCID 88921334, compound

Procedure

The desired intermediate was prepared by treating 3-azabicyclo[3.1.0]hexan-3-yl(4-hydroxy-8-methylnaphthalen-1-yl)methanone (above step-2 intermediate) with Tf2O using the similar procedure as described in Step-8 of Intermediate-22.

Sources & evidence

ORD record
ord-751a19c7cfb44495aacfafca3ad05979
Source dataset
uspto-grants-2015_04
Patent number
US09006442B2

Reaction notes

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