Water → hexyl 1H-imidazole-1-carboxylate

HRID 1470518Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1470518
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH:8]1[N:12]=[CH:11][N:10]([C:13](N2C=NC=C2)=[O:14])[CH:9]=1.O>ClCCl>[N:10]1([C:13]([O:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[O:14])[CH:9]=[CH:8][N:12]=[CH:11]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 81031-HexanolHCID 682631,1'-Carbonyldiimidazole

Produkt 1

HCID 57389745hexyl 1H-imidazole-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

A solution of n-hexanol (25.95 g) in dichloromethane (400 ml) was slowly added to solution of N,N-carbonyldiimidazole (48.08 g) in dichloromethane (100 ml) and stirred for 2½ hour at 25-35° C. Water was added to the reaction mixture. Both the dichloromethane layer and aqueous layer were separated and the dichloromethane layer was distilled under reduced pressure to provide the title compound. Yield: 60 g

Aufarbeitung

  1. customBoth the dichloromethane layer and aqueous layer were separated
  2. distillationthe dichloromethane layer was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b2f9fbffea754df8926700772fc09fb5
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09006448B2

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