HCID 131732729, compound → HCID 131732730, compound

HRID 1470665Notes

Reaction equation

HRID 1470665 reaction equation
[CH3:1][O:2][C:3](=[O:40])[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([NH:11][C:12]([C:14]2[C:19]([F:20])=[C:18]([F:21])[C:17]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([CH3:36])([CH3:35])[O:29][SiH2:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:24][CH:23]=3)=[C:16]([F:37])[C:15]=2[F:38])=O)[C:5]=1[NH2:39]>C(O)(=O)C>[CH3:1][O:2][C:3]([C:4]1[C:5]2[N:39]=[C:12]([C:14]3[C:15]([F:38])=[C:16]([F:37])[C:17]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([CH3:36])([CH3:35])[O:29][SiH2:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[CH:24][CH:23]=4)=[C:18]([F:21])[C:19]=3[F:20])[NH:11][C:6]=2[CH:7]=[C:8]([CH3:10])[CH:9]=1)=[O:40]

Participants

3

Reactant 1

HCID 131732729HCID 131732729, compound

Product 1

HCID 131732730HCID 131732730, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Amino-3-{[4′-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,5,6-tetrafluoro-biphenyl-4-carbonyl]-amino}-5-methyl-benzoic acid methyl ester (2.4 g, 4.16 mmol) was dissolved in glacial acetic acid (75 mL) and stirred and refluxed for 4 hours. Progress of the reaction was monitored by TLC. Acetic acid was distilled under vacuum and the resulting residue was quenched with ice cold water. The precipitate was washed with water and dried (2.0 g, 84.03%) which was directly taken to the next step.

Workup

  1. temperaturerefluxed for 4 hours
  2. distillationAcetic acid was distilled under vacuum
  3. customthe resulting residue was quenched with ice cold water
  4. washThe precipitate was washed with water
  5. customdried (2.0 g, 84.03%) which

Sources & evidence

ORD record
ord-3d6644825f8649aea3e47a0d8ce6809d
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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