Cesium carbonate → 5-(5-Bromopyridin-2-yloxy)pyrimidine

HRID 1470720Notes

Reaction equation

HRID 1470720 reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[OH:9][C:10]1[CH:11]=[N:12][CH:13]=[N:14][CH:15]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CC(N(C)C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([O:9][C:10]2[CH:11]=[N:12][CH:13]=[N:14][CH:15]=2)=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 10796Cesium carbonate

HCID 86666699HCID 86666699, compound

Product 1

HCID 666115945-(5-Bromopyridin-2-yloxy)pyrimidine

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Educts: 2,5-dibromo-pyridine/5-hydroxypyrimidine using cesium carbonate as base and DMA as solvent

Sources & evidence

ORD record: ord-df076f38cd8e4276ac9f01d577c63a9b
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006450B2

Reaction notes

Loading…