Acetic Anhydride → HCID 59578607, compound

HRID 1470723Notes

Reaction equation

HRID 1470723 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[N:14]=[CH:13][C:12]([NH2:15])=[CH:11][N:10]=1>ClCCl>[Cl:8][C:9]1[N:14]=[CH:13][C:12]([NH:15][C:5](=[O:7])[CH3:6])=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 122159932-Chloropyrimidin-5-amine

Product 1

HCID 59578607HCID 59578607, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

78 μL (0.83 mmol) acetic anhydride are added to 100 mg (0.77 mmol) 2-chloro-pyrimidin-5-ylamine in 20 mL dichloromethane at 0° C. Subsequently 115 μL TEA are added and stirring is continued for 12 h at rt. After that time, the solvent is removed by evaporation and the residue is washed with water.

Workup

  1. customAfter that time, the solvent is removed by evaporation
  2. washthe residue is washed with water

Sources & evidence

ORD record
ord-ce1fb2efe5d14334ba1bcbc5febd3e38
Source dataset
uspto-grants-2015_04
Patent number
US09006450B2

Reaction notes

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