反应详情

1.37 g (13.0 mmol) Cyanogen bromide are added to a mixture of 2.0 g (8.12 mmol) (S)—N-[1-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (V.1) and 4.86 mL (28.4 mmol) DIPEA in 15 mL THF and 15 mL dichloromethane. The mixture is stirred for 4 h at rt. After that time, the solvents are removed in vacuo. The residue is taken up in ethylacetate, the mixture is washed with water and the organic layer is concentrated. After addition of diethyl ether the precipitate is collected by filtration, followed by washing with diethylether to yield the desired product.

1. customAfter that time, the solvents are removed in vacuo
2. washthe mixture is washed with water
3. concentrationthe organic layer is concentrated
4. additionAfter addition of diethyl ether the precipitate
5. filtrationis collected by filtration
6. washby washing with diethylether