HCID 67125450, compound → HCID 67125411, compound

HRID 1470764Notes

Reaction equation

HRID 1470764 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[CH:12]=[N:13][C:14]([N:17]2[CH2:22][CH2:21][CH:20]([C:23]3[CH:28]=[CH:27][C:26]([C@@H:29]([NH:31][C:32](=[O:34])[CH3:33])[CH3:30])=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)=[N:15][CH:16]=1)=O>CC(O)=O>[NH:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:9]1[C:11]1[CH:12]=[N:13][C:14]([N:17]2[CH2:22][CH2:21][CH:20]([C:23]3[CH:28]=[CH:27][C:26]([C@@H:29]([NH:31][C:32](=[O:34])[CH3:33])[CH3:30])=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)=[N:15][CH:16]=1

Participants

3

Reactant 1

HCID 67125450HCID 67125450, compound

Product 1

HCID 67125411HCID 67125411, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 92 mg (S)-2-{4-[4-(1-acetylamino-ethyl)-phenyl]-piperidin-1-yl}-pyrimidine-5-carboxylic acid (2-amino-phenyl)-amide in 2 mL HOAc is refluxed for 12 h at 110° C. After concentration in vacuo water is added and the precipitate is collected by filtration to yield the desired product.

Workup

  1. concentrationAfter concentration in vacuo water
  2. additionis added
  3. filtrationthe precipitate is collected by filtration

Sources & evidence

ORD record
ord-d8e8ef4dd5534cfa92a796a010ec71c5
Source dataset
uspto-grants-2015_04
Patent number
US09006450B2

Reaction notes

Loading…