2-Ethylhexanoyl chloride → HCID 86692648, compound

HRID 1470832Notes

Reaction equation

HRID 1470832 reaction equation
[Al+3].[Cl-].[Cl-].[Cl-].[CH2:5]([CH:7]([CH2:11][CH2:12][CH2:13][CH3:14])[C:8](Cl)=[O:9])[CH3:6].[F:15][C:16]1[C:17]2[CH2:23][S:22][CH2:21][C:18]=2[S:19][CH:20]=1>C(Cl)Cl>[CH2:5]([CH:7]([CH2:11][CH2:12][CH2:13][CH3:14])[C:8]([C:20]1[S:19][C:18]2[CH2:21][S:22][CH2:23][C:17]=2[C:16]=1[F:15])=[O:9])[CH3:6]

Participants

5

Reactant 3

HCID 791032-Ethylhexanoyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 86692647HCID 86692647, compound

Product 1

HCID 86692648HCID 86692648, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.31 mmol of AlCl3 was added to 20 ml DCM with 2.31 mmol 2-ethylhexanoyl chloride at about 0° C. Compound 7 from the previous step was added to the mixture. The mixture was reacted at about 0° C. for about 4 hours. After reacting, the reactant was poured into ice water. The organic phase was extracted by ether 3 times. Compound 8 was purified by silica gel. The yield was about 70%.

Workup

  1. customThe mixture was reacted at about 0° C. for about 4 hours
  2. extractionThe organic phase was extracted by ether 3 times
  3. customCompound 8 was purified by silica gel

Sources & evidence

ORD record
ord-4f9d9652aeff457a8c413e668669cb50
Source dataset
uspto-grants-2015_04
Patent number
US09006568B2

Reaction notes

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