反应详情

The product from Example 29B (0.78 g, 1.15 mmol) was dissolved in dichloromethane (10 mL) at room temperature and treated with TFA (1.8 mL, 23.0 mmol) for 3 h. The residue was concentrated and partitioned between dichloromethane and sodium bicarbonate solution. The organics were concentrated and purified by chromatography on silica gel with a 40 g column, eluting with dichloromethane to give 0.218 g (43%) of the trans isomer.

1. concentrationThe residue was concentrated
2. custompartitioned between dichloromethane and sodium bicarbonate solution
3. concentrationThe organics were concentrated
4. custompurified by chromatography on silica gel with a 40 g column
5. washeluting with dichloromethane
6. customto give 0.218 g (43%) of the trans isomer