Hydrochloric Acid → HCID 178479713, compound

HRID 1470945Notes

Reaction equation

HRID 1470945 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]3[N:28]([C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)[CH:27]([C:36]4[CH:41]=[CH:40][C:39]([NH:42][C:43]([C@@H:45]5[CH2:49][CH2:48][CH2:47][N:46]5C(OC(C)(C)C)=O)=[O:44])=[CH:38][CH:37]=4)[CH2:26][CH2:25]3)=[CH:20][CH:19]=2)[N:17]=1)=O)(C)(C)C.[ClH:57]>O1CCOCC1>[ClH:57].[F:35][C:32]1[CH:33]=[CH:34][C:29]([N:28]2[CH:24]([C:21]3[CH:20]=[CH:19][C:18]([C:16]4[N:17]=[C:13]([C@@H:9]5[CH2:10][CH2:11][CH2:12][NH:8]5)[NH:14][CH:15]=4)=[CH:23][CH:22]=3)[CH2:25][CH2:26][CH:27]2[C:36]2[CH:41]=[CH:40][C:39]([NH:42][C:43]([C@@H:45]3[CH2:49][CH2:48][CH2:47][NH:46]3)=[O:44])=[CH:38][CH:37]=2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451943HCID 178451943, compound

Product 1

HCID 178479713HCID 178479713, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Dissolved the product from Example 39H (350 mg, 0.458 mmol) in 4M hydrochloric acid in dioxane solution (6 mL) and stirred the solution at room temperature for 30 min then concentrated the mixture under high vacuum to a solid (approx. 310 mg) as a hydrochloride salt that was used directly in the next reaction.

Workup

  1. concentrationthen concentrated the mixture under high vacuum to a solid (approx. 310 mg) as a hydrochloride salt that
  2. customwas used directly in the next reaction

Sources & evidence

ORD record
ord-60ce6fe70f764cd2b6920b4c19d9437e
Source dataset
uspto-grants-2015_04
Patent number
US09006387B2

Reaction notes

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