Hydrochloric Acid → HCID 178440993, compound

HRID 1470950Notes

Reaction equation

HRID 1470950 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]3[N:28]([C:29]4[CH:34]=[CH:33][C:32]([C:35]([CH3:38])([CH3:37])[CH3:36])=[CH:31][CH:30]=4)[CH:27]([C:39]4[CH:44]=[CH:43][C:42]([NH:45][C:46]([C@H:48]5[CH2:52][CH2:51][CH2:50][N:49]5C(OC(C)(C)C)=O)=[O:47])=[CH:41][CH:40]=4)[CH2:26][CH2:25]3)=[CH:20][CH:19]=2)[N:17]=1)=O)(C)(C)C.[ClH:60]>O1CCOCC1>[ClH:60].[C:35]([C:32]1[CH:31]=[CH:30][C:29]([N:28]2[CH:24]([C:21]3[CH:20]=[CH:19][C:18]([C:16]4[N:17]=[C:13]([C@@H:9]5[CH2:10][CH2:11][CH2:12][NH:8]5)[NH:14][CH:15]=4)=[CH:23][CH:22]=3)[CH2:25][CH2:26][CH:27]2[C:39]2[CH:40]=[CH:41][C:42]([NH:45][C:46]([C@H:48]3[CH2:52][CH2:51][CH2:50][NH:49]3)=[O:47])=[CH:43][CH:44]=2)=[CH:34][CH:33]=1)([CH3:38])([CH3:36])[CH3:37]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451942HCID 178451942, compound

Product 1

HCID 178440993HCID 178440993, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 40E (610 mg, 0.76 mmol), in 2M hydrochloric acid in dioxane solution (10 mL) was reacted according to the procedure in Example 39I to provide the title compound (495 mg) as a hydrochloride salt and a mixture of stereoisomers.

Sources & evidence

ORD record
ord-9ed4e8d85bbd45e289b79e0e7935b901
Source dataset
uspto-grants-2015_04
Patent number
US09006387B2

Reaction notes

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