4-(2-Fluoro-4-nitrophenyl)morpholine → 3-Fluoro-4-morpholinoaniline

Participants

Reaction Steps

A solution of the compound of Example 120A (2.26 g, 10.00 mmol) in ethyl acetate (35 mL) was treated with 10% palladium on carbon (300 mg) followed by hydrogenation under one atmosphere pressure for 6 h. The mixture was filtered through celite and concentrated in vacuo to afford the title compound as a white solid.

Provenance & Evidence