1,4-Dioxane hydrochloride → (s)-5-Bromo-2-(pyrrolidin-2-yl)-1h-imidazole hydrochloride

HRID 1471005Notes

Reaction equation

HRID 1471005 reaction equation
[Br:1][C:2]1[NH:6][C:5]([C@@H:7]2[CH2:11][CH2:10][CH2:9][N:8]2C(OC(C)(C)C)=O)=[N:4][CH:3]=1.[ClH:19].O1CCOCC1>>[ClH:19].[Br:1][C:2]1[NH:6][C:5]([C@@H:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 56605192tert-Butyl (2S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Product 1

HCID 49780402(s)-5-Bromo-2-(pyrrolidin-2-yl)-1h-imidazole hydrochlorideYield 100%

Procedure

A mixture of Example 126E (5.0 g, 15.8 mmol) in 4M HCl/Dioxane (40 mL) was allowed to stir for one hour. The mixture was concentrated to afford 3.99 g (100%) of the title compound. MS (ESI) m/z 217 (M+H)+.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-688d23c53a5e4526840772d9a12f2483
Source dataset
uspto-grants-2015_04
Patent number
US09006387B2

Reaction notes

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