1,4-Dioxane hydrochloride → HCID 86649125, compound

HRID 1471042Notes

Reaction equation

HRID 1471042 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]([C:16]3[CH:17]=[CH:18][C:19]4[N:23]=[C:22]([C@@H:24]5[CH2:28][CH2:27][CH2:26][N:25]5[C:29](=[O:39])[C@@H:30]([NH:34][C:35]([O:37][CH3:38])=[O:36])[CH:31]([CH3:33])[CH3:32])[NH:21][C:20]=4[CH:40]=3)[CH2:14][CH2:13][CH:12]2[C:41]2[CH:46]=[CH:45][C:44]([C:47]3[NH:51][C:50]([C@@H:52]4[CH2:56][CH2:55][CH2:54][N:53]4C(OC(C)(C)C)=O)=[N:49][CH:48]=3)=[CH:43][CH:42]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:64].O1CCOCC1>O1CCOCC1>[Cl-:64].[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH:15]([C:16]3[CH:17]=[CH:18][C:19]4[N:23]=[C:22]([C@@H:24]5[CH2:28][CH2:27][CH2:26][N:25]5[C:29](=[O:39])[C@@H:30]([NH:34][C:35]([O:37][CH3:38])=[O:36])[CH:31]([CH3:33])[CH3:32])[NH:21][C:20]=4[CH:40]=3)[CH2:14][CH2:13][CH:12]2[C:41]2[CH:46]=[CH:45][C:44]([C:47]3[NH:51][C:50]([C@@H:52]4[CH2:56][CH2:55][CH2:54][NH2+:53]4)=[N:49][CH:48]=3)=[CH:43][CH:42]=2)=[CH:9][CH:10]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67236614HCID 67236614, compound

Product 1

HCID 86649125HCID 86649125, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from example 191K (0.11 g, 0.28 mmole) was dissolved in dioxane (2 mL), then added 4N HCl/dioxane (1 mL). The resulting solid mass is stirred 30 minutes at room temperature. The solvent is removed in vacuo leaving a tan solid as the title compound as a mixture of isomers (0.092 g) which stored under vacuum overnight.

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-b8d9f566714b462a8dcd166dc47fbaf3
Source dataset
uspto-grants-2015_04
Patent number
US09006387B2

Reaction notes

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