Bromochloromethane → HCID 66627948, compound

HRID 1471272Notes

Reaction equation

HRID 1471272 reaction equation
[N:1]12[CH2:8][CH2:7][N:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:9][CH2:10][Cl:11]>CC(C)=O>[Br-:9].[Cl:11][CH2:10][N+:1]12[CH2:8][CH2:7][N:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2

Participants

4

Reactant 2

HCID 6333BromochloromethaneHCID 9237Dabco

Product 1

HCID 66627948HCID 66627948, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

20 ml Of acetone, 4.0 g of 1,4-diazabicyclo[2.2.2]octane, and 20 ml of bromochloromethane, were added to a flask, capped, and stirred at room temperature. Within 45 minutes white precipitate had formed. After 3.5 hours the mixture was cooled to 0-5 C, filtered, washed with three 10 ml portions of cold acetone, and dried under reduced pressure overnight. 2.31 g Of a white solid was obtained.

Workup

  1. customcapped
  2. customWithin 45 minutes white precipitate had formed
  3. temperatureAfter 3.5 hours the mixture was cooled to 0-5 C
  4. filtrationfiltered
  5. washwashed with three 10 ml portions of cold acetone
  6. customdried under reduced pressure overnight

Sources & evidence

ORD record
ord-4ccb9977d0fb4d12a8b7879d15a1854f
Source dataset
uspto-grants-2015_04
Patent number
US09011734B2

Reaction notes

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