Methanol → HCID 178446053, compound

HRID 1471302Notes

Reaction equation

HRID 1471302 reaction equation
[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:36].[Br-:28].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33]

Participants

5

Reactant 3

HCID 887MethanolHCID 6106L-LeucineHCID 178480554HCID 178480554, compound

Product 1

HCID 178446053HCID 178446053, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Tiotropium bromide (1.9 g) and L-leucine (0.3 g) were dissolved into 60 ml methanol. Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined below.

Workup

  1. customdried

Sources & evidence

ORD record
ord-6f3ca96593ce4a2e91cc8b6c20b4b318
Source dataset
uspto-grants-2015_04
Patent number
US09011923B2

Reaction notes

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