HRID1471303

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2083

Salbutamol

C13H21NO3

HCID7570

4,4'-Diphenylmethane diisocyanate

C15H10N2O2

HCID67940

2H-Perfluoropropane

C3HF7

结构：CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2.O.[Br-]

HCID178456315

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2.O.[Br-]

HCID178449105

未命名化合物

PROCEDURE

实验过程

pMDI Manufacture: Spray dried salbutamol sulphate:ipratropium bromide (22.5 mg) was added into a coated (DuPont 3200 200) canister, with Bespak 63 μl valve. HFA 227 (17000 mg) was added to the canister. The solution was shaken.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a2198acbbae04c049a63ff3179a0c409
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09011923B2
来源说明: uspto-grants-2015_04

反应 SMILES

C1C(CC2C=CC(N=C=[O:16])=CC=2)=CC=C(N=C=O)C=1.[CH3:20][C:21]([NH:24][CH2:25][CH:26]([OH:36])[C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([CH2:34][OH:35])[CH:28]=1)([CH3:23])[CH3:22].[CH3:37][CH:38]([N+:40]1([CH3:60])[C@@H:44]2[CH2:45][C@@H:46]([O:48][C:49]([CH:51]([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:52][OH:53])=[O:50])[CH2:47][C@H:41]1[CH2:42][CH2:43]2)[CH3:39].O.[Br-:62].C(F)(C(F)(F)F)C(F)(F)F>>[CH3:23][C:21]([NH:24][CH2:25][CH:26]([OH:36])[C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([CH2:34][OH:35])[CH:28]=1)([CH3:20])[CH3:22].[CH3:39][CH:38]([N+:40]1([CH3:60])[C@@H:44]2[CH2:45][C@@H:46]([O:48][C:49]([CH:51]([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:52][OH:53])=[O:50])[CH2:47][C@H:41]1[CH2:42][CH2:43]2)[CH3:37].[OH2:16].[Br-:62]