Salbutamol → HCID 178449105, compound

HRID 1471303Notes

Reaction equation

C1C(CC2C=CC(N=C=[O:16])=CC=2)=CC=C(N=C=O)C=1.[CH3:20][C:21]([NH:24][CH2:25][CH:26]([OH:36])[C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([CH2:34][OH:35])[CH:28]=1)([CH3:23])[CH3:22].[CH3:37][CH:38]([N+:40]1([CH3:60])[C@@H:44]2[CH2:45][C@@H:46]([O:48][C:49]([CH:51]([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:52][OH:53])=[O:50])[CH2:47][C@H:41]1[CH2:42][CH2:43]2)[CH3:39].O.[Br-:62].C(F)(C(F)(F)F)C(F)(F)F>>[CH3:23][C:21]([NH:24][CH2:25][CH:26]([OH:36])[C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([CH2:34][OH:35])[CH:28]=1)([CH3:20])[CH3:22].[CH3:39][CH:38]([N+:40]1([CH3:60])[C@@H:44]2[CH2:45][C@@H:46]([O:48][C:49]([CH:51]([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:52][OH:53])=[O:50])[CH2:47][C@H:41]1[CH2:42][CH2:43]2)[CH3:37].[OH2:16].[Br-:62]

Participants

Reactant 4

HCID 2083Salbutamol

HCID 7570Diphenylmethane diisocyanate

HCID 679401,1,1,2,3,3,3-Heptafluoropropane

HCID 178456315HCID 178456315, compound

Product 1

HCID 178449105HCID 178449105, compound

Procedure

pMDI Manufacture: Spray dried salbutamol sulphate:ipratropium bromide (22.5 mg) was added into a coated (DuPont 3200 200) canister, with Bespak 63 μl valve. HFA 227 (17000 mg) was added to the canister. The solution was shaken.

Sources & evidence

ORD record: ord-a2198acbbae04c049a63ff3179a0c409
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09011923B2

Reaction notes

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