HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-4-iodopyridin-3-ol → 4-(5-Chloro-furo[2,3-c]pyridin-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-4-iodopyridin-3-ol | HCID 53302038 | — |
| Reactant | Tert-butyl 4-ethynyl-4-methylpiperidine-1-carboxylate | HCID 72207605 | — |
| Product | 4-(5-Chloro-furo[2,3-c]pyridin-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester | HCID 86694576 | — |
Reaction Steps
The title compound is prepared from 4-ethynyl-4-methyl-piperidine-1-carboxylic acid tert-butyl ester and 2-chloro-5-hydroxy-4-iodo-pyridine following a procedure analogous to that described for Intermediate 5. LC (method 4): tR=1.76 min; Mass spectrum (ESI+): m/z=351/353 (Cl) [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012456B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-656974988d974e928253fe26d99163a9 |
| Source note | uspto-grants-2015_04 |