反应详情

Ethyl 1-(4-methoxybenzyl)-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 2 and POCl3 were heated at 80° C. in a sealed tube for 3 hours. Reaction mixture was concentrated in vacuo, diluted with diethylether, washed with water, dried over sodium sulfate and concentrated in vacuo to afford product 3 as off white solid.

1. customReaction mixture
2. concentrationwas concentrated in vacuo
3. additiondiluted with diethylether
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo