Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenylhydrazine | HCID 7516 | — |
| Reactant | Ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | HCID 53665897 | — |
| Product | HCID 178490900 | HCID 178490900 | — |
Reaction Steps
A suspension of compound 3 and 10 equivalents of phenyl hydrazine was stirred at 90° C. for 16 hours. Reaction was quenched with iced water. The aqueous layer was removed, residue was suspended in ethanol and stirred with 1N NaOH solution at room temperature for 1 hour. pH was adjusted to 5 using acetic acid and solvent was removed in vacuo. Compound 4 was collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09012470B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-8d98d11e5c3041d38e21729098d05b86 |
|---|
| Source note | uspto-grants-2015_04 |
|---|
