反应详情

温度

90 °C

A suspension of compound 3 and 10 equivalents of phenyl hydrazine was stirred at 90° C. for 16 hours. Reaction was quenched with iced water. The aqueous layer was removed, residue was suspended in ethanol and stirred with 1N NaOH solution at room temperature for 1 hour. pH was adjusted to 5 using acetic acid and solvent was removed in vacuo. Compound 4 was collected by filtration.

1. customReaction
2. customwas quenched with iced water
3. customThe aqueous layer was removed
4. stirringstirred with 1N NaOH solution at room temperature for 1 hour
5. customwas removed in vacuo
6. filtrationCompound 4 was collected by filtration