反应详情

温度

25 °C

To a solution of 2-phenyl-1-p-tolylethanone (3.00 g, 14.27 mmol) in THF (50.0 mL) was added KOtBu (30.0 mL, 30.0 mmol), CS2 (0.862 mL, 14.27 mmol) and dibromomethane (0.994 mL, 14.27 mmol). The reaction was stirred at 25° C. for 12 h, quenched with water (40.0 mL) and extracted with EtOAc (3×50.0 mL). The combined organics were dried over MgSO4, filtered, and concentrated to give the title compound as a brown oil without further purification. LCMS m/z=299.2 [M+H]+.

1. customquenched with water (40.0 mL)
2. extractionextracted with EtOAc (3×50.0 mL)
3. dry with materialThe combined organics were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated