1-Phenylpiperazine → 2-[5-(Dimethylphosphoryl)-3-methoxypyrazin-2-yl]-4-(4-phenylpiperazin-1-yl)-5-(trifluoromethyl)pyrimidine

HRID 1472003Notes

Reaction equation

HRID 1472003 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:14]1[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][N:17]=[C:16]([C:24]2[C:29]([O:30][CH3:31])=[N:28][C:27]([P:32]([CH3:35])([CH3:34])=[O:33])=[CH:26][N:25]=2)[N:15]=1>>[CH3:35][P:32]([C:27]1[N:28]=[C:29]([O:30][CH3:31])[C:24]([C:16]2[N:17]=[C:18]([N:10]3[CH2:11][CH2:12][N:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH2:8][CH2:9]3)[C:19]([C:20]([F:22])([F:23])[F:21])=[CH:14][N:15]=2)=[N:25][CH:26]=1)([CH3:34])=[O:33]

Participants

3

Reactant 2

HCID 70961-PhenylpiperazineHCID 866687964-Chloro-2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-5-(trifluoromethyl)pyrimidine

Product 1

HCID 681573702-[5-(Dimethylphosphoryl)-3-methoxypyrazin-2-yl]-4-(4-phenylpiperazin-1-yl)-5-(trifluoromethyl)pyrimidine

Procedure

This compound can be prepared by reacting 1-Phenylpiperazine with 4-chloro-2-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-5-(trifluoromethyl)pyrimidine as described in Example 36.

Workup

  1. customThis compound can be prepared

Sources & evidence

ORD record
ord-6a3af7b8fdd54356a40b4d6f951b3199
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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